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Fipronil is used in a wide variety of pesticide products, including granular products for grass, gel baits, spot-… Select the appropriate applicator size for the weight of the cat. For cats with or at risk from mixed infestations by cestodes, nematodes and ectoparasites. he product is not for use in kittens weighing less than 0.6 kg and/or under 7 weeks of age. This safety summary is a complement to the information on product labels and MSDS. (c) Copyright NOAH Compendium 2021. Frontline contains the active ingredients fipronil and s-methoprene. KEEP OUT OF REACH OF CHILDREN. PRECAUTIONARY STATEMENTS. Medication should never be administered without first consulting your veterinarian. Fipronil is quite lipophilic and when applied topically to animals it is deposited in the sebaceous glands of the skin, from where it is slowly released. A large amount (15 to 50%) of it is not absorbed in the gut but is excreted unchanged through the feces. Liability is also denied for any possible damage or harm to persons, animals or any other goods that could follow the transmission or use of the information, data or recommendations in this site by any site visitor or third parties. Sunlight quickly breaks down solved fipronil  (half-life <24 hours). up to 9 times the recommended dose), every 4 weeks for 3 treatments, without any adverse effects. Nevertheless, no this regarding guarantee is given, and any liability on its accuracy, integrity, sufficiency, actuality and opportunity is denied. Amazon's Choice for fipronil for cats. When applying the veterinary medicinal product, special attention should be paid in long hair breeds in order to ensure that it is applied directly to the skin and not on the hair, as this could lead to a lower bioavailability of the active substances and thus, to a reduced efficacy. Fipronil, an N-phenylpyrazole, was introduced into the United States in 1996 for use in animal health, indoor pest control, and commercial turf and crop protection. For this reason disposal of fipronil residues (e.g. Transient salivation and/or vomiting could also be observed, in both kittens and adult cats, in isolated cases. WHO Acute Hazard classification of pesticides, In a one-year study fipronil was administered daily to, The primary symptoms of intoxication with fipronil and other, Other symptoms reported after fipronil poisoning include. Fluralaner plus moxidectin was non-inferior to fipronil (P < 0.0001) at all assessments and superior to fipronil at 2 and 8 weeks for the proportion of cats free of ticks (P < 0.0001). Shelf life of the veterinary medicinal product as packaged for sale: 2 years. This allows a rather long residual effect against several external parasites, e.g. 99 $32.99 $32.99. The dose of fipronil is based on the weight of the dog and pipettes are available in 0.67 ml (for dogs up to 22 pounds), 1.34 ml (for dogs 23 to 44 pounds), 2.68 ml (for dogs 45 to 88 pounds) and 4 ml (for dogs 89 to 132 pounds). PETARMOR Plus Flea & Tick Prevention for Cats with Fipronil, Waterproof, Long-Lasting & Fast-Acting Topical Cat Flea Treatment. As other phenylpyrazoles, fipronil is an inhibitor of GABA (gamma-aminobutyric acid)-gated chloride channels in nerve cells, a key neurotransmittor in the central nervous system. A temporary clumping or spiking of the hair and mild and transient skin reactions at the application site (itching, hair loss) have been commonly observed at the application site after treatment in clinical studies. Stored applicators must be kept in the intact blister package. I alternate treating each cat so each cat only gets one dose every two months minimizing any health risk from the treatment. Remove one applicator tube from the package and … Don't worry, this means it's working! Fipronil is a broad use insecticide that belongs to the phenylpyrazole chemical family. Fleas are all-too-common visitors to both cats and dogs. Frontline Plus for cats is an easy to apply topical spot-on treatment for cats suffering from flea and tick infestations. National regulatory authorities determine whether a product is approved for a given indication , i.e. Fipronil is also formulated as insect bait for roaches, ants and termites; as sprays for pets; and as a granular turf product to control mole crickets. WARNING !!! If eye irritation persists or if side effects are noted, seek medical advice and show the package leaflet or the label to the physician. It also attacks the flea life stages and prevents future occurrence of fleas and ticks. To determine the proper Frontline Plus dosage for your dog, start by weighing your dog so you can buy the box that matches your dog’s size. I have two cats and I treat each one alternately and the flea issue is kept under control. 97 mg/kg LD50 acute, dogs, p.o. Do not use in cases of hypersensitivity to the active substances or to any of the excipients. View the full product label for application information. 9.6%. Besides erroneous dosing, overdosing can occur due to. Treatment should not be extrapolated from one animal to the other without veterinary opinion. The use of the veterinary medicinal product should exclusively be based on the confirmed mixed infestations or significant risk of such mixed infestations with ectoparasites and nematodes (including for heartworm disease prevention), and where concurrent treatment against cestodes is indicated. EFFIPRO Topical Solution for Cats Caution. - Treatment and prevention of infestations by fleas (. Select the appropriate applicator size for the weight of the cat. In case of accidental eye exposure flush the eyes thoroughly with water, as the product can cause slight mucous membrane and eye irritation. KEEP OUT OF REACH OF CHILDREN. People with a known hypersensitivity to fipronil, (S)-methoprene, eprinomectin or praziquantel or to any of the excipients should avoid contact with the veterinary medicinal product. Symptoms appear a few hours after exposure, but depend strongly on the formulation, the dose and the kind of contact (skin, inhalation, ingestion etc). As a precaution, it is not recommended to bathe animals within 2 days after topical treatment. LD50 acute, rats, p.o. Temporary excessive salivation was commonly observed following licking the application site after treatment in clinical trials. Fipronil spray for dogs. SAFETY. The Meeting allocated an acute reference dose of 0.003 mg/kg bw for both fipronil and fipronil-desulfinyl on the basis of the NOAEL of 0.3 mg/kg bw per day in a study of neurotoxicity in rats given repeated doses of fipronil, and a safety factor of 100. A fast-acting solution, this Merial product kills 100% adult fleas within just 12 hours and ticks and chewing lice within 48 hours. Fipronil. The dose is 0.0305ml/pound. Irrespective of the weight of your cat, you should apply the contents of one applicator, once a month. This way, it’s harder for them to lick off. All Rights Reserved. The information in this page must not be confused with the Materials and Safety Datasheets (MSDS) officially issued by manufacturers for active ingredients and many other chemicals. ducks). Oral ingestion of the veterinary medicinal product resulted in common to uncommon vomiting, hyper-salivation and/or in transient neurological signs such as ataxia, disorientation, apathy and pupil dilation in safety studies. However fipronil's binding affinity to GABA receptors of invertebrates is much higher than to GABA receptors in vertebrates. Marketing Authorisation Holder (if different from distributor), Boehringer Ingelheim Animal Health UK Ltd, www.boehringer-ingelheim.co.uk/­animal-health/­animal-health. Fipronil is a topical solution that collects in the oils of the skin and in the hair follicles. MSDSs target safety during manufacturing, transport, storage and handling of such materials. Handling of treated animals should be limited until the application site is dry, and children should not be allowed to play with treated animals during this period. The safety of the veterinary medicinal product has not been established during pregnancy and lactation. Correct application will minimise the occurrence of such events. Our vet says: You should never ever apply dog spot on treatments to cats, or to any animal other that what it is intended for. Special precautions to be taken by the person administering the veterinary medicinal product to animals. Here’s a chart showing the dosage breakdown for Activyl. The monthly dosage for cats and kittens is 0.50 mL (0.017 fl oz), which is one full tube. DO NOT ALLOW YOUR CAT TO INGEST THIS PRODUCT. Contains Fipronil, the active ingredient used in Frontline Top Spot ... DO NOT EXCEED RECOMMENDED DOSAGE AMOUNT FOR CATS. Spot-on solution. Do not smoke, drink or eat during application. Contrary to many myths, they are equally at home in a clean house as a dirty one so you needn't be embarrassed to ask for help with controlling them. Avoid contact of the applicator content with the fingers. Read the article on fipronil safety in this site. chicken) but not to other ones (e.g. Dosage: The recommended minimum doses are 10 mg/kg bodyweight for fipronil, 12 mg/kg for (S)-methoprene, 0.5 mg/kg for eprinomectin and 10 mg/kg for praziquantel. Acute Toxicity and Tolerance of Fipronil. It is important to apply the veterinary medicinal product to a skin area where the cat cannot lick it off: on the neck, in between shoulders. This mechanism exists not only in insects but also in mammals and other vertebrates. Therefore, epidemiological information about current susceptibility of the target species should be taken into account in order to limit the possibility of a future selection for resistance. This causes hyperexcitation of contaminated insects' nerves and muscles. However, since the attachment of single ticks after treatment cannot be excluded, transmission of infectious diseases cannot be completely ruled out. Use only according to the benefit-risk assessment by the prescribing veterinarian. Common Precautions. For example, if your dog weighs 22.5 pounds, use the 5 to 22 pound box. Amounts to be administered and administration route. Arrives before Christmas. It is therefore recommended that recently treated animals do not sleep with owners, especially children. Even the biggest dose, for dogs over 40kg, is less than a teaspoon. The veterinary medicinal product is not intended for use in dogs. - Treatment and prevention of infestations by ticks (, - Treatment of infestations with tapeworms (, - Treatment of infestations with gastrointestinal nematodes (L3, L4 larvae and adults of, - Treatment of infestations with feline lungworms (L3 larvae, L4 larvae and adults of, - Treatment of infestations with vesical worms (. Finished products contain one or more active ingredients, but also other ingredients that can be relevant from the safety point of view. in empty containers) in watercourses must be absolutely avoided. The dosage for dogs varies considerably from the dosage that’s required by cats as the dosage for canines is determined by their weight. Fipronil is highly toxic to fish and aquatic invertebrates. In case of massive flea infestation and at the beginning of the control measures, these areas should be treated with a suitable environmental product and then vacuumed regularly. The absorbed fipronil is found predominantly in fatty tissues. : Never use on cats pipettes approved only for dogs. Be aware that the safety instructions for the same veterinary medicine may vary from country to country. Frontline Plus for Cats contains 9.8 percent of Fipronil, 11.8 percent of (S) Methoprene with the higher concentration of active ingredients than the one for dogs. After application, fipronil spreads and sequesters in the lipids of the skin and hair follicles, and continues to be released onto the skin and coat, … No data on the effect of bathing/shampooing on the efficacy of the product in cats is available. Fipronil is quite stable in soils, with a half-life of ~125 days. The recommended dose for cats is 25 – 166.6 mg indoxacarb/kg bodyweight, equivalent to 0.128 – 0.85 mL/kg bodyweight. Fipronil's effects take about 24 hours to begin and last about 30 days. use on a particular host at a specific dose and against a specific parasite . Mild and transient neurological signs such as ataxia, disorientation, apathy and pupil dilation may be observed, with spontaneous recovery the day after. In addition to flea and tick control, fipronil may be used to control chewing lice and to treat Cheyletiellosis. What about the dosage? Fipronil was first registered for use in the United States in 1996. Avoid contact with the cat's eyes. WHO Acute Hazard classification of pesticides: Class II, moderately hazardous. Cats in areas endemic for heartworm, or those which have travelled to endemic areas, may be infected with adult heartworms. Acute reference dose for fipronil. (adsbygoogle = window.adsbygoogle || []).push({}); Click here for a list and overview of all safety summaries of antiparasitic active ingredients in this site. Laboratory studies with the individual ingredients in rats and rabbits have not produced teratogenic, foetotoxic or maternotoxic effects. Multiply 0.0305 times your pet’s weight for dose (package instructions) (can be used in lower doses with same effect) Cats 1-10 pounds - 0.5ml 0.3ml for 10lbs 0.45 for 15lbs Fipronil is almost insoluble in water. On very rare occasions, symptomatic treatment can be required. In the absence of risk of co-infestation, the use of a narrow spectrum parasiticide should be considered as a first line therapy. The veterinary medicinal product is exclusively indicated when all three groups are targeted at the same time. To kill fleas, all stages of Brown Dog Ticks, American Dog Ticks, Lone Star Ticks, and Deer Ticks, chewing lice and mosquitoes, apply to cats and kittens as follows: 1. The concentration of the active constituent in fipronil products registered in Australia varies marginally from the USA, with Frontline spray containing 2.5 g/L (0.25%) fipronil and the topical concentrate containing 100 g/L (10%) fipronil, according to the approved label for these products (APVMA website). Some dog breeds may present increased susceptibility to macrocyclic lactones, potentially leading to signs of neurotoxicity. After accidental ingestion stomach lavage as well as administration of active charcoal administration and laxatives is recommended. up to 15 times the recommended dose) in healthy kittens aged 7 weeks and older treated up to 6 times at four-week intervals. 640 mg/kg LD50 acute, chicken, p.o. Each pipette of Frontline flea treatment for cats contains Fipronil. - very rare (less than 1 animal in 10,000 animals treated, including isolated reports). Fipronil is used to control ants, beetles, cockroaches, fleas, ticks, termites, mole crickets, thrips, rootworms, weevils, and other insects. I have two cats and dogs containing applicators of 3 x 0.9 ml ticks 48! This way, it is not recommended to bathe animals within 2 days after topical treatment veterinarian! Which then causes them to lick off a moldy odor to control chewing within... Veterinary use on cats that weigh between 2 and 5 pounds cats Medication should never be without... Solvents ( e.g: never use on cats that weigh between 2 5. 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